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By | June 7, 2022

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This is a script intended for personal use only. In no event shall
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Control of the immune response by myeloid-derived suppressor cells.
Myeloid-derived suppressor cells (MDSC) are present in the tumor microenvironment. MDSC are a heterogeneous population of cells containing myeloid progenitors, immature myeloid cells, and mature granulocytes, macrophages, and dendritic cells (DC). MDSC are comprised of two distinct subpopulations: CD11b(+)Gr-1(+) monocytic MDSC (M-MDSC) and CD11b(+)Gr-1(-) granulocytic MDSC (G-MDSC). Both subsets arise in different hematopoietic organs. In addition to a direct immunosuppressive effect, MDSC can also act as antigen-presenting cells (APC) and promote tumor growth by creating an immunosuppressive microenvironment. There is a reciprocal relationship between MDSC and T-cells in the tumor microenvironment; thus, MDSC expansion is associated with poor prognosis. In addition, MDSC have been shown to be active in various inflammatory diseases. The immunomodulatory function of MDSC is achieved through the production of arginase-1 and reactive oxygen species. Recently, specific inhibition of MDSC expansion by targeting the colony-stimulating factor-1 receptor (CSF-1R) has been shown to result in increased tumor control. Understanding the role of MDSC in tumor development, metastasis, and immunosuppression may provide new targets for cancer therapy.[Exchange transfusion in hemoglobinopathy].
Exchange transfusion is a regular treatment in chronic thalassemia and sickle cell anemia. This treatment is recommended in patients with acute anemia of various origins. Exchange transfusion cannot be suggested in patients with high risk of transfusion-associated graft versus host disease or hemolytic diseases of the newborn. The

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Topic:
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